Pancreatic cancer is a type of cancer that starts in the pancreas. It accounts for about 3% of all cancers in the U.S. and about 7% of all cancer deaths, according to the American Cancer Society. Pancreatic cancer is diagnosed slightly more commonly in men than in women.
The pancreas sits just behind the stomach, about the size of a hand, and is important for digestion because it creates the enzymes that break down sugars, fats and starches. The pancreas also makes hormones that regulate blood sugar levels and appetite, stimulate stomach acids and alert your stomach when it is time to empty.
Pancreatic adenocarcinoma is the most common type of pancreatic cancer, making up about 95% of cancers in the exocrine pancreas. It occurs when exocrine cells, which make up most of the pancreas and form the exocrine glands and ducts, start to grow out of control. Exocrine glands are responsible for releasing enzymes into the intestines to help you digest foods (especially fats).
Pancreatic neuroendocrine tumors (NETs) are a less common type, making up less than 2% of pancreatic cancers, but tend to have better outcomes. These tumors start in neuroendocrine cells, a special kind of cell found in the pancreas that helps to make important hormones like insulin and glucagon (which help control blood sugar levels).
Pancreatic cancer is hard to detect early, even during routine physical exams, because people usually have no symptoms until the cancer gets larger or spreads.
People who are at higher risk or have a family history can get genetic testing to see if they have inherited conditions that could lead to pancreatic cancer. At Our Lady of the Lake Cancer Institute, we have a High-Risk Pancreas Cancer Screening Clinic led by John Lyons, MD, a surgical oncologist, that identifies patients at higher-than-average risk of pancreas cancer and enroll them in a screening program for early detection of pancreas cancer.
Curing pancreas cancer requires a combination of surgery and chemotherapy, and oftentimes radiation therapy.